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Research Publications

• Published work

• In press

R & D STHS, makes a number of publications on basic and clinical research. These are not just in support of the compounds under study but also to support the International scientific community initiatives against major human diseases. These publications are in major peer-reviewed Journals.

Published work

The following publications and presentations were made:

2005

• Virmani MA, Gaetani F. The metabolic approach to neuroprotection:  role of the mitochondrial permeability transition pore (mPTP). 4^th World Conference of the International Coenzyme Q₁₀ Association, Beverly Hills, CA April 14-17, 2005.
   
• Virmani MA, Binienda Z, Ali S, Gaetani F.  Role of nutrition in drug abuse. The International Society for Neurochemistry/European Society for Neurochemistry. Isola di San Servolo, Venice, Italy, August 16 – 19, 2005
   
• Binienda Z, Robinson BL, DeCoursey B, Przybyla-Zawislak BD, Virmani A, Amato A, Ali SF. Methamphetamine and 3-nitropropionic acid-induced selective changes in body temperature and alterations in monoaminergic neurotransmission. Isola di San Servolo, Venice, Italy, August 16 – 19, 2005.
   

• Virmani A, Gaetani F, Binienda Z. Effects of metabolic modifiers such as carnitines, coenzyme Q₁₀, and PUFAs against different forms of neurotoxic insults: metabolic inhibitors, MPTP, and methamphetamine. Ann NY Acad Sci 2005;1053:183-91.
   

• Binienda Z, Przybyla-Zawislak B, Virmani A, Schmued L. L-Carnitine and neuroprotection in the animal model of mitochondrial dysfunction. Ann NY Acad Sci 2005;1053:174-82.
   
• Przybyla-Zawislak BD, Thorn BT, Ali SF, Dennis RA, Amato A, Virmani A, Binienda ZK. Identification of rat hippocampal mRNAs altered by the mitochondrial toxicant, 3-NPA. Ann NY Acad Sci 2005;1053:162-73.
   

2004

• Binienda Z,   Summage JL, Dufour S,  Przybyla-Zawislak B, Virmani A, Slikker W Jr, Schmued L. Effect of L-carnitine pretreatment against 3-nitropropionic acid (3-NPA) induced neurotoxicity. International Society of Toxicology Conference, Baltimore, March 21-25, 2004.
   
• Virmani A, Gaetani F, Binienda Z, Xu A, Duhart H, Ali SF. Role of mitochondrial dysfunction in neurotoxicity of MPP+: partial protection of PC12 cells by acetyl-L-carnitine. Ann NY Acad Sci 2004;1025:267-73.
   
• Binienda Z, Virmani A, Przybyla-Zawislak B, Schmued L. Neuroprotective effect of L-carnitine in the 3-nitropropionic acid (3-NPA)-evoked neurotoxicity in rats. Neurosci Lett 2004;367(2):264-7. 
   
• Virmani A, Binienda Z. Role of carnitine esters in brain neuropathology. Mol Aspects Med 2004;25(5-6):533-49. 
   
• Virmani A, Gaetani F, Binienda Z.  Effects of carnitines against different forms of neurotoxic insults: metabolic inhibitors, MPTP and methamphetamine. The 7^th International Conference on Neuroprotective Agents. Monterey, California, November 14  - 18, 2004.
   
• Binienda Z, Virmani A, Schmued L. Neuroprotective effects of L-carnitine pretreatment in 3-nitropropionic acid (3-NPA)-evoked neurotoxicity.  The 7^th International Conference on Neuroprotective Agents. Monterey, California, November 14  - 18, 2004.
   
• Virmani A, Gaetani F, Binienda Z, Ali S. The metabolic approach to neuroprotection. Third International Conference on Mechanisms of Action of Nutraceuticals. Haywood County, North Carolina. November 12-14, 2004.
   

 2003

• Virmani A, Gaetani F, Imam S, Binienda Z, Ali S. Possible mechanism for the neuroprotective effects of L-carnitine on methamphetamine-evoked neurotoxicity. Ann NY Acad Sci 2003;993:197-207; discussion 287-8.
   

• Binienda Z, Virmani A. The mitochondriotropic effects of L-carnitine and its esters in the central nervous system. Medl Chem (Central Nervous System Agents) 2003;3(4):275-82.
   
• Przybyla-Zawislak B, Summage JL, Sapienza PP, Ross IA, Virmani A, Ali SF, Kim CS, Binienda ZK. Free fatty acids and activator protein-1 transcripts  response to the acute 3-NPA exposure in rats. Neuroscience conference, Nov 8-12, 2003.
   
• Virmani MA, Gaetani F, Ali S, Binienda Z. Hypothesis - Modulation of the mitochondrial membrane permeability as a strategy in reducing neurotoxicity of methamphetamine. ISN/APSN Satellite meeting - Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity, July 2003 Kyoto, Japan.
   
• Binienda ZK, Przybyla Zawislak B, Summage J, Sapienza PP, Ross IA, Virmani A, Ali SF, Kim CS. Free fatty acids and activator protein-1 transcripts response to the acute 3-nitropropionic acid (3-NPA) exposure in rats. 2003 Abstract: Society for Neuroscience, Washington, DC.
   

2002

• Virmani A, Gaetani F, Imam S, Binienda Z, Ali S. The protective effects of mitochondriotropic agent L-carnitine on methamphetamine-evoked toxicity in the CNS. 6^th International Neuroprotective Agents Conference, Hilton Head, South Carolina, September 15-19, 2002.
   

• Virmani A, Gaetani F, Imam S, Binienda Z, Ali S. The protective role of L-carnitine against neurotoxicity evoked by drug of abuse, methamphetamine, could be related to mitochondrial dysfunction. Ann NY Acad Sci 2002; 965:225-32.
   

2001

• Virmani A, Gaetani F, Imam S, Binienda Z, Ali S. Protective effect of L-carnitine against neurotoxicity evoked by drugs of abuse, methamphetamine, in mice. American Society For Neurochemistry. Cellular and Molecular Mechanisms of Drugs of Abuse, Mar del Plata, Argentina, August 22 - 24, Abst No. 61, pg 84. 2001.
   
• Virmani MA,Caso V, Spadoni A, Russo F, Rossi S, Gaetani F. Action of acetyl-l-carnitine on the neurotoxicity evoked by amyloid fragments on primary rat cortical neurones. Proc NY Acad Sci 2001;939:162-78.
   

2000

• Virmani MA, Caso V. Action of acetyl-l-carnitine on the neurotoxicity evoked by amyloid fragments on primary rat cortical neurones. 5^th International Conference on Neuroprotective Agents: Clinical and Experimental Aspects, Lake Tahoe, California, September 17-21, 2000.
   

• Mancinelli R, Vargiu R, Licheri D, Naimi S, Capra A, Virmani A, Littarru GP. Formulation of oxidative phosphorylation substrates improves motor functions of skeletal, cardiac and smooth muscles. 2^nd Conference of the International Coenzyme Q₁₀ Association, Frankfurt, Germany Dec 1-3 2000

In press

• Binienda Z, Przybyla-Zawislak B,  Robinson B, Virmani A, Amato A, Ali S. Effects of L-carnitine pre-treatment in Methamphetamine and 3-nitropropionic acid-induced neurotoxicity. Ann NY Acad Sci. 2006 In Press
   
• Virmani MA, Binienda Z, Ali S, Gaetani F. Links between nutrition, drug abuse and the metabolic syndrome.  Ann NY Acad Sci. 2006 In Press

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