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Polyunsaturated
Fatty Acids (PUFA).
CALVANI M. AND
BENATTI P.
Introduction
Dietary
polyunsaturated fatty acids (PUFA) have effects on diverse
physiological processes impacting normal health and
chronic disease, such as the regulation of plasma lipid
levels, cardiovascular and immune function, insulin
action, and neuronal development and visual function.
Ingestion of PUFA will lead to their distribution to
virtually every cell in the body with effects on membrane
composition and function, eicosanoid synthesis, and
signaling as well as the regulation of gene expression.
Cell specific lipid metabolism, as well as the expression
of fatty acid-regulated transcription factors likely play
an important role in determining how cells respond to
changes in PUFA composition.
This review will focus on recent advances on the
essentiality of these substances and on their interplay
with cell physiology leading to new perspective in
different therapeutically fields.
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